心舒康对大鼠急性心肌缺血保护作用的研究

Protective effects of Xin Shukang capsule on rat with acute myocardial ischemia

目的观察心舒康胶囊对急性心肌缺血大鼠血浆及心肌组织降钙素基 因相关肽（CGRP）、内皮素（ET）的影响,探讨其防治缺血性心脏病的作用机制.方法：采用雄性Wistar 大鼠为研究对象,随机分为阳性对照组（复方丹参片）、心舒康胶囊高、中、低剂量组、模型组和空白对照组,按实验方案喂养后,检测大鼠血浆及心肌组织CGRP、ET 情况.结果：模型对照组CGRP、ET 含量与空白对照组比较有统计学意义（P 〈 0.01）;心舒康大剂量组CGRP、ET 含量与与模型对照组比较有明显变化,且与阳性对照组基本接近.结论：心舒康胶囊对实验性大鼠急性心肌缺血具有明显的保护作用.调节CGRP、ET 水平可能是其作用机制之一.

Objectiv:To observe the protective effects of Xin Shukang capsule on rat with acute myocardial ischemia in the experimen.Methods:50 rats were randomly divided into six groups, positive control group,Xin Shukang capsule high and medium and low dose group,model group, blank control group.Then fed according to experimental program,the changes of CGRP and ET of serum and myocardium were observed.Results:There was obvious diffrences between model group and blank control group of CGRP and ET(P < 0.01),the diffrences between model group and Xin Shukang high dose group also obviously.Conclusion:Xin Shukang capsule has protective effects on rat with acute myocardial ischemia.Adjust the level of CGRP and ET may be one of its mechanisms.