紫外线诱导角质形成细胞炎症反应信号传导机制研究进展

Signal transduction mechanisms underlying ultraviolet-induced inflammatory responses in keratinocytes

紫外线（UV）是一种可以导致皮炎、光老化和癌变的重要的环境因子，UV诱导表皮角质形成细胞炎症因子的生成是上述疾病发生的重要分子事件。UV诱导角质形成细胞炎症涉及多种受体、细胞内信号传导相关调控分子和核转录因子的参与，主要包括表皮生长因子受体、芳香烃受体、过氧化物酶体增生物激活受体、蛋白激酶C家族、蛋白激酶B、丝裂原活化蛋白激酶家族、核转录因子κB和转录因子激活蛋白等，构成了复杂的炎症信号传导网络。

Ultraviolet （UV） is a kind of important environmental factor that can cause dermatitis, photoaging and skin eaneerization. The UV-induced production of inflammatory factors by epidermal keratinocytes has been deemed an important molecular event in occurrence of the above diseases. Various receptors, intracellular signal transduetion-related regulatory molecules and nuclear transcription factors are involved in UV-induced inflammatory responses in keratinocytes, which mainly include epidermal growth factor receptor, aryl hydrocarbon receptor, peroxisome proliferatoractivated receptor, protein kinase C family, protein kinase B, mitogen-activated protein kinase family, nuclear factor-κB and transcription factor activator protein-l, etc, and constitute a complex inflammatory signal transduction network.