逍遥散联合心理干预对高考月经不调患者激素水平的影响

Effects of Xiaoyaosan Combined with Psychological Intervention on Hormone Levels of College Entrance Examination patients with Irregular Menstruation

目的:观察逍遥散联合心理干预对高考月经不调患者激素水平的影响。方法:将52例高考月经不调患者按随机数字表法分为对照组和观察组,各26例。对照组患者给予逍遥散360 ml,bid;观察组患者在对照组基础上给予针对性心理干预治疗。两组患者均治疗3个月。观察两组患者临床疗效及治疗前后孕酮(P)、雌二醇(E2)、黄体生成素(LH)、卵泡刺激素(FSH)、泌乳素(PRL)水平的变化情况。结果:观察组患者总有效率显著高于对照组(96.15%vs.84.62%),差异有统计学意义(P<0.05)。治疗前后,两组患者P、E2、LH、FSH、PRL水平组间比较,差异均无统计学意义(P>0.05);治疗后,两组患者P、E2、LH、FSH水平显著升高,PRL水平显著降低,与治疗前比较,差异有统计学意义(P<0.01)。结论:高考女生月经不调是由于腺垂体或下丘脑功能异常,FSH、LH、E2、P等激素减少所致,逍遥散联合心理干预可以增强高考月经不调患者治疗效果,但在激素水平调节方面未能显示出心理干预的优势。

OBJECTIVE：To observe the effects of Xiaoyaosan combined with psychological intervention on hormone levels of college entrance examination girls with irregular menstruation. METHODS：52 college entrance examination girls with irregular menstruation were randomly divided into control group and observation group with 26 cases in each group. Control group was given Xiaoyaosan 360 ml,bid;observation group was additionally given psychological intervention on the basis of treatment control group. 2 groups of patients were treated for 3 months. Before and after treatment,clinical efficacy,progesterone（P）,estradiol（E2）,luteinizing hormone（LH）,follicle stimulating hormone（FSH）and prolactin（PRL）were observed in treatment groups,and then compared with control group. RESULTS：The total effective rate of treatment observation group was significantly higher than that of treatment control group（96.15% vs. 84.62%）,with statistical significance（P0.05）. Before treatment and after treatment,compared with control group the levels of P,E2,LH,FSH and PRL in two groups were lower,with not statistical significance（P0.05）;after treatment,the levels of P,E2,LH and FSH in two groups increased significantly,but PRL level decreased significantly,there was statistical significance between before treatment and after treatment（P0.01）. CONCLUSIONS：The pituitary can＇t excrete enough FSH,LH,E2,P,which is the main cause of irregular menstruation in college entrance examination girls. Xiaoyaosan can effectively treat this kind of irregular menstruation by adjusting the functions of the hypothalamic-pituitary-ovarian axis,and adjunctive therapy of psychological intervention can increase curative effect.