CD44抗原对乳腺癌患者耐药性的影响

Effects of CD44 Antigen on Drug Resistance of Breast Cancer Patients

目的:探讨CD44抗原对乳腺癌患者耐药性的影响。方法:选取乳腺癌患者62例,所有患者均采用表柔比星75 mg/m2+环磷酰胺600 mg/m2方案化疗。化疗前后,以免疫组化法检测患者的CD44抗原表达情况,以世界卫生组织标准评价耐药性,观察乳腺癌组织中CD44抗原的变化情况,比较两组患者临床疗效。结果:治疗后,敏感患者48例,总有效率为77.42%,耐药患者14例,无效率为22.58%,差异有统计学意义(P<0.05);化疗后,所有患者癌组织中的CD44抗原高表达率高于化疗前,耐药患者CD44抗原高表达率高于敏感患者,差异有统计学意义(P<0.01)。结论:CD44抗原与乳腺癌化疗耐药性密切相关,高表达CD44抗原可以作为乳腺癌化疗耐药性的一个重要参考指标。

OBJECTIVE：To evaluate the effect of CD44 on drug resistance of breast cancer patients. METHODS：62 breast cancer patients were selected,and the expression of CD44 was detected by immunohistochemical method. Drug resistance was evaluated by WHO criteria,and the expression of CD44 in breast tissue was observed after observation. RESULTS：There were 48 patients sensitive to CD44 and 14 patients with drug resistance,with statistical significance（P0.05）. After chemotherapy,the expression of CD44 in caner tissue was higher than before chemotherapy,that of patients with drug resistance was higher than patients sensitive to CD44,with statistical significance（P0.01）. CONCLUSIONS：CD44 antigen is closely related to chemotherapy resistance of breast cancer,and high expression of CD44 can be used as an important indicator for breast cancer chemotherapy.