呋喃妥因分子印迹电化学传感器的制备及应用

The Preparation and Application of Nitrofurantoin Molecular-Imprinted Electrochemical Sensor Based on Glassy Carbon Electrode

以甲基丙烯酸为功能单体,呋喃妥因为模板分子,马来松香丙烯酸乙二醇酯（EGMRA）为交联剂,在玻碳电极表面制备了呋喃妥因分子印迹膜。采用循环伏安（CV）法、差分脉冲伏安（DPV）法及交流阻抗（EIS）法对印迹膜进行表征。实验表明,DPV法测定的氧化峰电流与呋喃妥因浓度在8.0×10-8~5.0×10-6 mol/L范围内呈良好的线性关系（R=0.9939）,检出限为6.5×10-8 mol/L。该传感器用于呋喃妥因肠溶片的测定,其回收率为96.6%~101.6%。

A molecular imprinted electrochemical sensor has been developed for the detection of nitrofurantoin（NTF）by using NTF as the template molecule,methyl acrylic acid as the functional monomer,and ethylene glycol maleic rosinate acrylate（EGMRA）as the cross-linker.The performance of the sensor was investigated by cyclic voltammetry（CV）,differential pulse voltammetry（DPV）and electrochemical impedance spectroscopy（EIS）.A linear relationship between oxidation peak current and concentration of NTF was obtained over a range from 8.0×10-8 to 5.0×10-6 mol·L-1（r=0.9939）with a detection limit（S/N=3）of 6.5×10-8 mol·L-1.The imprinted sensor was successfully used to determine NTF in pills with recoveries ranging from 96.6%to 101.6%.