结直肠癌组织中HER2表达水平与肿瘤的发生、发展及浸润转移的相关性研究

The role of research in colorectal cancer and HER2 expression levels,development and invasion and metastasis

目的探讨结直肠癌组织中人类表皮生长因子受体-2(HER-2)表达水平与肿瘤组织的发生、发展及浸润转移的相关性。方法采用免疫组化SP法对2012年1月至2014年12月实施手术治疗的176例结直肠癌患者的正常组织与癌变组织中HER-2表达水平进行比较。同时就患者不同年龄、性别、肿瘤大小、部位、组织分化程度、浸润深度、病理分期及淋巴结转移与否的HER-2表达情况进行统计学分析。结果癌组织的HER-2表达水平明显高于正常组织,差异有统计学意义(P<0.01);HER-2表达水平与组织分化程度呈负相关(相关系数r=-0.356),与病理分期呈正相关(r=0.534);浸润深度在浆膜下、浆膜外的患者HER-2表达的过表达明显高于浸润深度在黏膜下、肌层的患者;具有淋巴转移的患者中HER-2过表达明显高于无淋巴转移的患者(P<0.05);但患者的性别及肿瘤大小、部位对HER-2表达水平无统计学差异(P>0.05)。结论 HER-2的表达水平可作为判断结直肠癌发生、发展、浸润及转移的有效指标之一,具有一定的临床应用价值。

Objective To investigate the correlation between colorectal cancer and HER-2 expression levels in tumor tissue,development,invasion and metastasis. Methods Sp immunohistochemical method was used to detect normal tissue and cancerous tissue between January 2012 to December 2014 receiving surgery treatment of 176 cases of colorectal cancer patients. The HER-2 expression levels,patient age,gender,tumor size on the extent of the site,differentiation,depth of invasion,pathological stage and lymph node metastasis under HER-2 expression were analyzed. Results HER-2 expression was significantly different in normal tissue and cancer tissue（ P〈0. 01）,while a certain relationship was detected in the expression and tissue differentiation and pathological staging（ the correlation coefficients were-0. 356,0. 534）. In addition to significant differences existed（ P〈0. 05） in the invasion and metastasis,gender,tumor size and location had no significant effect on the expression of HER-2（ P〉0. 05）. Conclusion One effective indicator of HER-2 expression level could be used as the occurrence of colorectal cancer development,invasion and metastasis. The index has some clinical value.