摘要
输血相关急性肺损伤（TRALI）是指输血后6h内发生的急性肺损伤（ALI），是输血导致患者死亡的主要原因之一。目前对TRALI发病机制的假说包括“二次打击”学说与“阈值模型”学说等。超过80％TRALI是由输注的血液制品中含特异性抗人类白细胞抗原（HLA）或人类中性粒细胞抗原（HNA）抗体介导的，并且导致TRALI发生的血液制品，主要来源于有多次妊娠史的女性献血者。目前，多个国家实行以男性献血者为主体，供应高血浆含量血液制品的临床预防、控制TRALI策略，以效降低TRALI发生率。笔者拟就TRALI的定义、发病机制、诊断、预防控制策略进行综述。
Transfusion-related acute lung injury （TRALI） which occurs acute lung injury （ALI） within 6 hours after transfusion is one of the leading causes of death in patients with blood transfusion. Several hypothesises have been proposed to explain the underlying pathologic mechanisms of TRALI, such as ＂two-event＂ and ＂threshold model＂ hypothesis, etc.. Immune-mediated TRALI accounts for over 80% of reported cases of TRALI which was mediated by HLA （human leucocyte antigen） or human neutrophil antigens （HNA） antibodies in transfused blood products. Immune-mediated TRALI is commonly associated with donor plasma transfusion or other blood products from multiparous women, which has led many countries to reduce or exclude women from donating high-volume plasma products. This policy has resulted in a decrease in the incidence of TRALI. This article reviews the definition, pathogenesis, diagnosis, prevention and control strategies of TRALI.
出处
《国际输血及血液学杂志》
CAS
2016年第1期81-84,共4页
International Journal of Blood Transfusion and Hematology
基金
广西壮族自治区自然科学基金项目（2013GXNSFBA019206）
南宁市科学研究与技术开发计划项目（科技惠民重大科技专项）（20133141）
