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两个C2轴对称环十肽的合成 被引量：1

Synthesis of Two C2 Symmetrical Cyclic Decapeptide
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摘要 以亮氨酸和苯丙氨酸为原料,通过氨基酸的保护以及脱保护、氨基酸的甲基化和耦合,最后以O-苯并三氮唑-N,N,N'N'-四甲基脲四氟硼酸酯(TBTU)/2-(7-偶氮苯并三氮唑)-N,N,N',N'-四甲基脲六氟磷酸酯(HATU)/3-(二乙氧基磷酰氧基)-1,2,3-苯并三嗪-4-酮(DEPBT)为环合试剂,合成2个C2轴对称环十肽化合物Q10-1与Q10-2,最后环合收率分别为31.6%和39%。通过HPLC进行分离纯化,经HPLC检测产物纯度均在98%以上,通过1HNMR,13CNMR和ESI-MS对两个化合物进行表征。 With leucine and phenylalanine as raw materials,synthesized two C2 symmetrical cyclic decapeptide compounds Q10- 1 and Q10- 2 in assistance of protection and deprotection of amino acids,the amino acid methylation and coupling,and TBTU / HATU / DEPBT as cyclization reagents. The cyclization yield reached 31. 6% and 39%. The products were isolated and purified by HPLC,which the purity of product was up to 98% detected by HPLC. The compound structures were characterized by means of1 HNMR,13CNMR and ESI-MS.
作者 陈建维 白德发 钟生辉 曲桐 徐石海
机构地区 暨南大学生命科学技术学院化学系
出处 《精细化工》 EI CAS CSCD 北大核心 2016年第2期162-167,194,共7页 Fine Chemicals
基金 国家自然科学基金(21172094 41376155 21372100 U1301131) 广州市科技项目(2013000000163) 国家高技术研究发展计划(863计划)(2013AA092902)~~
关键词 海洋环肽 环十肽 表征 医药原料 marine cyclopeptide cyclopentapeptide characteristics drug materials
分类号 O629.725 [理学—有机化学]
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参考文献13

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同被引文献12

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精细化工
2016年 第2期

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