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上皮—间质转化在恶性肿瘤中发生机制的研究进展 被引量：23

Research Progress in Carcinogenesis Mechanism of Epithelial-Mesenchymal Transition in Cancer
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摘要 研究表明肿瘤细胞发生上皮—间质转化(EMT)时所涉及的分子机制相当复杂,涉及到的信号通路在转录、翻译和翻译后水平均发挥调控作用。全文就EMT在恶性肿瘤中发生机制的研究进展作一综述。 Researches showed that there are complex molecular mechanism in epithelialmesenchymal transition（EMT） of tumor cells. These signaling pathways involved in EMT play regulation roles in the transcriptional,translational and post-translational levels. The recent progress in carcinogenesis mechanism of EMT in cancer was discussed in this paper.
作者 陈文浩 杨明 张艳桥
机构地区 哈尔滨医科大学附属肿瘤医院
出处 《中国肿瘤》 CAS 2016年第1期51-57,共7页 China Cancer
关键词 上皮—间质转化 恶性肿瘤 机制 epithelial-mesenchymal transition cancer mechanism
分类号 R73 [医药卫生—肿瘤]
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参考文献47

  • 1Inoue T,Umezawa A,Takenaka T,et al. The contribution of epithelial-mesenchymal transition to renal fibrosis dif- fers among kidney disease models[J]. Kidney Int,2015,87 (1) :233-238.
  • 2Lim SH,Becker TM,Chua W,et al. Circulating tumour cells and the epithelial mesenchymal transition in colorec- tal cancer[J]. J Clin Pathol,2014,67(10):848-853.
  • 3Dong C,Wu Y,Wang Y,et al. Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer[J].Oncogene, 2013,32(11) : 1351-1362.
  • 4Li Y,Zhao Z,Xu C,et al. HMGA2 induces transcription factor slug expression to promote epithelial-to-mesenchy- mal transition and contributes to colon cancer progression [J].Cancer Lett, 2014,355(1): 130-140.
  • 5De Craene B, Berx G. Regulatory networks defining EMT during cancer initiation and progression [J]. Nat Rev Can- cer ,2013,13(2) :97-110.
  • 6Way TD,Huang JT,Chou CH,et al. Emodin represses TWISTl-induced epithelial-mesenchymal transitions in head and neck squamous cell carcinoma cells by inhibit- ing the 13-catenin and Akt pathways[J]. Eur J Cancer,2014, 50(2) : 366-378.
  • 7Wang T,Li Y,Wang W,et al. Twist2,the key Twist iso- form related to prognosis,promotes invasion of cervical cancer by inducing epithelial-mesenchymal transition and blocking senescence[J]. Hum Pathol,2014,45(9): 1839-1846.
  • 8Teng Y, Li X. The roles of HLH transcription factors in epithelial mesenchymal transition and multiple molecular mechanisms[J].Clin Exp Metastasis, 2014,31 (3) : 367-377.
  • 9Diaz-Lopez A, Diaz-Martin J, Moreno-Bueno G,et al. Zebl and Snaill engage rniR-200f transcriptional and epigenetie regulation during EMT[J]. Int J Cancer,2015,136(4):E62- E73.
  • 10Yang X,Li L,Huang Q,et al. Writ signaling through Snaill and Zebl regulates bone metastasis in lung cancer [J].Am J Cancer Res, 2015,5(2) :748-755.

同被引文献229

引证文献23

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中国肿瘤
2016年 第1期

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