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SIRT1诱导慢性炎症致肺癌发生发展的研究进展 被引量:2

Research Progress in Mechanism of Chronic Inflammation-driven Lung Cancer Induced by SIRT1
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摘要 沉默信息调节因子1(silent information regulator 1,SIRT1)可能通过影响机体免疫系统,从而作用于细胞增殖以及恶性转化的炎症微环境,最终影响到肺癌的发生和发展。因此,SIRT1成为临床治疗肺癌的潜在新靶点。全文主要针对SIRT1诱导肺慢性炎症导致肺癌发生发展的分子机制做一综述。 Silent Information Regulator 1(SIRT1) acts on the microenvironment of cell proliferation and malignant transformation,via affecting human immune system. Therefore,SIRT1 might be a novel therapeutic target in lung cancer. This review aims at making a summary about the mechanism of SIRT1 inducing lung cancer caused by chronic inflammation.
出处 《中国肿瘤》 CAS 2016年第2期107-112,共6页 China Cancer
基金 浙江省医药卫生科研基金资助(2016KYB039)
关键词 沉默信息调节因子1 炎症 肺癌 信号转导通路 SIRT1 inflammation lung cancer signal transduction pathway
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