消化系统肿瘤肝转移的治疗策略

Therapeutic strategy of liver metastasis from malignant digestive system tumors

转移是消化系统恶性肿瘤发展的终末阶段,而肝脏是其血源性转移最好发的部位.转移性肝癌的治疗主要有手术治疗、全身化疗、RFA、门静脉栓塞术、肝动脉导管栓塞术等不同手段.消化系统肿瘤肝转移的治疗仍处于探索阶段,不同治疗方法对不同瘤种的治疗效果不尽相同,临床工作者需要以多学科团队诊断与治疗为基础,围绕患者的疾病特点,制订系统化的综合治疗方案.但是随着临床经验的积累、新型有效化疗药物的出现以及肝转移灶手术适应证的拓展和大样本循证医学证据的涌现,消化系统肿瘤肝转移的治疗必将朝着一个越来越规范和有效的方向发展.

Metastatic cancer is often occurred in advanced digestive system tumors and the most involved organ is liver.Multiple therapeutic managements and strategies such as surgery,systemic chemotherapy,radiofrequency ablation,portal vein embolization and transarterial chemoembolization are used in the treatment of liver metastasis.However,the treatment of advanced digestive system tumors liver metastasis is still challenging,different therapeutic methods show different results for different tumors,comprehensive treatment should be used based on features of patients and muliidisciplinary cooperation.With the accumulation of clinical experiences,the emergence of novel chemotherapeutics,wider indications of surgical resection in treating liver metastases and accumulated evidence from randomized controlled trials,the therapeutic management of metastatic hepatic cancer should be standardized and more effective in the future.