2型糖尿病患者颈动脉斑块与外周血白细胞计数相关分析

Correlation between Atherosclerosis of Carotid Artery and White Blood Cell Count in the Elderly People with Type 2 Diabetes Mellitus

目的:探讨扬州地区中老年2型糖尿病人群颈动脉内中膜增厚及粥样斑块的患病率、危险因素及其与外周血白细胞计数的关系。方法:通过颈部血管超声检查颈动脉,测量身高、体重、血压,应用全自动生化分析仪测定空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、脂蛋白a(LP-a)。应用全自动血液分析仪进行外周血白细胞(WBC)测定。应用高压液相色谱法检测糖化血红蛋白(HbA1c)。应用电化学发光夹心免疫测定血清胰岛素。应用酶联免疫吸附法测定血清视黄醇结合蛋白4(RBP-4)。结果:调查人群中颈动脉内中膜增厚、粥样斑块的患病率分别为35.4%、29.2%。多因素Logistic回归分析表明颈动脉粥样斑块危险因素的危险度由大到小分别为:高LDL-C、高HOMA-IR、男性、高HbA1c、高外周血白细胞计数、吸烟、高RBP-4。结论:扬州地区中老年2型糖尿病患者颈动脉粥样硬化的患病率较高,其危险因素包括高LDL-C、高HOMA-IR、男性、高HbA1c、高外周血白细胞计数、吸烟、高RBP-4。

Objective：To investigate the correlation of white blood cell count（WBCC） with atherosclerosis of carotid artery in the elderly people with type 2 diabetes mellitus（T2DM ） .Methods：WBCC was measured with automated cell counters via standard techniques .Height ,weight ,blood pressure（BP） ,fasting blood glucose（FBG） ,hemoglobin A1c （HbA1c） ,total cholesterol （TC） ,triglyceride（TG） ,low-density lipoprotein cholesterol（LDL-C） ,high-density lipopro-tein cholesterol（HDL-C） and Lipoprotein（a）（Lp-a） were determined by routine laboratory methods .The retinol bind-ing protein 4（RBP-4） was measured by an enzyme-linked immunoabsorbent assay and the insulin concentration was measured by an electrochemiluminescence sandwich immunoassay .Results：Within the survey population carotid intima thickening plaque prevalence was 35 .4% and 29 .2% .Multivariate Logistic regression analysis showed that there were seven factors associated with the occurrence of carotid artery atherosclerosis and its risk descending were：high LDL-C , high HOM A-IR ,male ,high HbA1c ,high WBCC ,smoking and high RBP-4 .Conclusion：A high prevalence of athero-sclerosis of carotid artery was found in the elderly people with T2DM ,which was associated with high LDL-C ,high HOMA-IR ,male ,high HbA1c ,high WBCC ,smoking and high RBP-4 .