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绝经后妇女冠心病与血清载脂蛋白、血脂及性激素的关系探讨 被引量:2

RELATIONSHIP OF SERUM LIPIDS,APOLIPOPROTEINS AND SEX HORMONES WITH CORONARY HEART DISEASE IN POSTMENOPAUSAL WOMEN
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摘要 作者测定了25例自然绝经后患冠心病的妇女及与之1:1配对的对照组妇女的血脂(TG、TC、HDL-C)、载脂蛋白(apoAⅠ、apoAⅡ、apoB100)及性激素(E_1、E_2、P、T)。结果显示:冠心病组TG及apoAⅠ/apoB100比率显著高于对照组,apoAⅡ显著低于对照组,其余各指标两组间无明显差异。血E_1与TG有关,P与apoB100正相关,提示性激素与绝经后妇女冠心病的发生似无直接联系,但雌激素和孕激素对血脂或载脂蛋白的代谢有一定影响。本文logistic回归分析显示,血TG、apoAⅠ、apoAⅡ对绝经后妇女冠心病的发生有重要的预测价值。 The study was carried out in 25 post-menopausal women with coronary heartdisease(CHD)and 25 matched controls.Age,menopusal time, body mass index,hyper-tention, smoking and occupation in CHDwere not different from those in the con-trol group. Serum lipids, apolipoproteins(apo), sex hormones and gonadotropin hor-mones were measured. Serum TG and apoAⅠ/apoB100 ratio increased more signifi-cantly in CHD than in the control group.Serum apo AⅡ decreased more significantlyin CHD than in the control group. Otherserum factors in CHD were not significant-ly different from those in the control group.Matched logistic regression analysis showedthat serum TG tal apo AⅠwere probablerisk factor, serum apoAⅡ was a protectedfactor of CHD, and all of them were im-portant predictors for CHD in postmeno-pausal women. Our results suggest that sexhormones seem to have important effects onthe occurrence of CHD by esterone (E_1) andprogesterone(p) interrupting serum lipid andapolipoprotein metabolism. Serum E_1, isrelated with TG, P is positively relatedwith apo B100.
出处 《华西医科大学学报》 CAS CSCD 1989年第4期409-412,共4页 Journal of West China University of Medical Sciences
关键词 绝经 冠心病 载脂蛋白 性激素 血脂 Postmenopause Coronary heart disease Apolipoproteins Serum lipids Sex hormone
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参考文献2

  • 1张廷杰,杜传礼.高甘油三酯血症研究现状[J]心血管病译文,1986(04).
  • 2王棠海,杨小龙.血清高密度脂蛋白—胆固醇磷硫铁铵显色法[J]江西医药,1982(S2).

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