期刊文献+

云克治疗绝经后乳腺癌骨质疏松患者50例临床疗效观察 被引量:3

原文传递
导出
摘要 乳腺癌是一种雌激素依赖性的肿瘤,对于雌、孕激素受体均为阳性的患者,可以进行内分泌辅助治疗,疗效确切。但因其原理是通过抑制雌激素的水平,达到抑制肿瘤细胞生长的目的,随之而来会出现骨钙质减少和骨质疏松。骨折风险增加。绝经后患乳腺癌的妇女更是骨质疏松的高危人群。
作者 孙建民
出处 《中国冶金工业医学杂志》 2016年第1期35-36,共2页 Chinese Medical Journal of Metallurgical industry
  • 相关文献

参考文献3

二级参考文献51

  • 1杨玲,殷晓进.锶与骨矿代谢[J].中国骨质疏松杂志,2004,10(3):384-387. 被引量:17
  • 2丁桂芝,刘忠厚,周勇.中西医结合防治骨质疏松症的基础与临床研究进展[J].中国骨质疏松杂志,1997,3(2):81-84. 被引量:121
  • 3Irina M, LiLian IP, Cecilia LS, et al. Extrncellar sigoal-kinase and calcium channels are involved in the proliferative effect of bisphosphonates on osteoblastic cells in vitro. J Bone Miner Res, 2001,16: 2050-2056.
  • 4Luckman SP, Hughs DE, Coxon FP, et al. Netrogen-containing bisphosphonates inhabit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including ras. J Bone Miner Res,1998, 13: 1668-1678.
  • 5Fisher JE, Rogers MJ, Hslasy JM, et al. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption and kinase activation in vitro. Proc Natl Acad ,Sci USA, 1999
  • 6Dunford JE, Thompson K, Coxon FP, et al. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitroge-containing bisphosphonates. J Pharmacol Exp Ther, 2001, 296: 235-242.
  • 7Frith JC, Monkkonen J, Auriola S, et al. The molecular mechanism of action of the anteresorptive and antiinflammatory drug clodronate: evidence for the formation, in vivo of a metabolite that inhabits bone resorption and causes osteoclast and macrophage a
  • 8Green JR, Clezardifl P. Mechanisms of bisphosphonates effects on osteoclasts, tumor cell growth, and metastasis. Am J Clin Oncol, 2002, 25:S3-9.
  • 9Giuliani N, Pedrazzoni M, Passeri G, et al. Bisphosphonates inhibit IL6 production by human ostcoblast-liks cells. Scand J Rheumatol, 1998,27: 38-41.
  • 10Viereck V, Emons G, Lauck V, et al. Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts. Biochem Biophys Res Commun, 2002, 291:680-686.

共引文献63

同被引文献38

引证文献3

二级引证文献23

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部