中药干预表皮生长因子受体抑制剂相关皮疹的荟萃分析

Effects of traditional Chinese medicine on epidermal growth factor receptor inhibitors induced rash:a meta-analysis

目的:探索中药干预表皮生长因子受体抑制剂(EGFRIs)相关皮疹的疗效及安全性。方法:检索Pubmed、Cochrane对照试验、中国学术期刊数据库、中国知网数据库中关于中药干预EGFRIs相关皮疹的随机对照试验,并手工检索补充相应文献。采用Revman软件对符合标准的随机对照试验进行荟萃分析。进行异质性检验及敏感性分析,潜在的发表偏倚采用"漏斗图"分析。结果:中药干预后EGFRIs相关皮疹的缓解程度、中医症状缓解总效应明显优于对照组(P<0.01);实体瘤治疗总有效率、疾病控制率与未予中药干预组相当(P>0.05)。中药干预组患者生活质量明显改善,均未出现治疗相关的不良反应。漏斗图分析及敏感性分析结果提示荟萃分析结果稳定可靠。结论:中药干预可明显缓解EGFRIs相关皮疹,明显缓解中医临床症状,改善患者生活质量,且不影响EGFRIs抗肿瘤疗效。

Objective：To evaluate the effect of traditional Chinese medicines（TCM）on epidermal growth factor receptor inhibitors（EGFRIs）induced rash.Methods：We conducted a systemic search of Pubmed database,Cochrane database,China Science Periodical Database（CSPD）and China National Knowledge Infrastructure（CNKI）using the following words：randomized controlled trails（RCT）,TCM,EGFRIs and rash.RCT trails in human were included.Meta-analysis was performed by using Revman software.Heterogeneity analysis and sensitivity analysis were done,publication biases were detected by a funnel plot analysis.Results：TCM intervention significantly improved EGFRIs induced rash and symptoms defined by the TCM（P 0.01）.The objective response rate and disease control rate of TCM group was equivalent to controls.In TCM group,patients＇ quality of life was improved.Conclusion：TCM could significantly relieve EGFRIs induced rash and symptoms,improve patients＇ quality of life.