血尿酸水平与帕金森病及左旋多巴制剂的相关性研究

Association between serum uric acid level and levodopa therapy in Parkinson's disease patients

目的探讨血尿酸水平与帕金森病(PD)的关系,以及左旋多巴制剂对PD患者血尿酸水平的影响。方法选取PD患者203例作为病例组,根据患者是否接受左旋多巴制剂治疗将病例组再分为治疗组160例和非治疗组43例。选取同期入院健康体检者252例作为对照组。比较各组血尿酸水平。结果病例组血尿酸水平显著低于对照组[(227.1±74.4)mmol/L vs(284.4±63.4)mmol/L,P<0.01],治疗组男性血尿酸水平较非治疗组男性下降更为显著[(213.8±69.3)mmol/L vs(291.8±80.1)mmol/L,P<0.01]。对年龄进行校正,男性PD血尿酸水平与病程(r=-0.211,P=0.010)、左旋多巴制剂每日服用剂量(r=-0.394,P=0.000)、累计治疗时间(r=-0.241,P=0.003)呈负相关;女性PD血尿酸水平与左旋多巴每日服用剂量呈负相关(r=-0.357,P=0.010)。结论应用左旋多巴制剂可能使血尿酸水平进一步降低。尿酸可能是PD的生物标记物之一。

Objective To study the association between serum uric acid（UA）level and levodopa therapy in Parkinson＇s disease（PD）patients.Methods Two hundred and three PD patients served as a PD group which was further divided into treatment group（n=160）and non-treatment group（n=43）,and 252 healthy persons served as a control group.Their serum UA levels were measured.Results The serum UA level was significantly lower in PD group than in control group and in male PD patients of treatment group than in those of non-treatment group（P〈0.01）.The serum UA level was negatively associated with the disease duration,daily levodopa dosage and accumulated levodopa treatment time in male PD patients（r=-0.211,P=0.010;r=-0.394,P=0.000;r=-0.241,P=0.003）and was positively associated with the daily levodopa dosage in female PD patients（r=-0.357,P=0.010）.Conclusion Levodopa can further reduce the serum UA level in PD patients and UA may be a biological marker of PD.