调节性T细胞在结节病发病中的相关性研究

Study on the relationship of regulatory T cells in the pathogenesis of sarcoidosis

目的研究调节性T细胞（Treg细胞）特异性转录因子在结节病患者肺和淋巴结组织中的表达水平，探讨Treg细胞在结节病发病中的作用。方法选择2002年1月～2013年12月在上海长征医院经临床病理确诊为结节病患者的肺组织8例和淋巴结组织20例，同时以非结节病手术切除的肺组织13例和淋巴结组织37例作为对照组，通过免疫组化检测结节病组和对照组中Treg细胞转录因子（FoxP3）表达水平。结果结节病组中Treg细胞水平特异性转录因子较对照组低（P〈0．05）。结论Treg细胞可能参与结节病的发病过程。

Objective To study the expression of specific transcription factors of regulatory T cells （ Treg cells ） in lung and lymph node tissue of patients with sarcoidosis, and to explore the role of Treg cells in the pathogenesis of sarcoidosis. Methods Their lung tissues and lymph node tissues were selected respectively in 8 and 20 patients with clinical and pathological confirmed sareoidosis in Shanghai Changzheng hospital from January 2002 to December 2013, and another 13 cases of non-operation resection lung tissues and 37 cases of lymph nodes were taken as the control group. The expression of Treg cell transcription factor （FoxP3） was detected and compared between the two gronps. Results The expression of FoxP3 was obviously lower in the sarcoidosis group than in the control group （ P 〈 0. 05 ）. Conclusion Treg cells may be involved in the pathogenesis of sarcoidosis.