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栀子苷对铜绿假单胞菌毒力因子及生物膜的影响 被引量:4

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摘要 细菌群体感应控制细菌毒力因子的分泌,抑制群体感应成为抗感染的新途径。本研究通过测定栀子的主要成分栀子苷对铜绿假单胞菌生长的影响,并检测其对铜绿假单胞菌群体感应调控的毒力因子及生物膜形成的影响,结果发现栀子苷的MIC为12.5 mg/m L。在亚抑菌浓度下,栀子苷能抑制铜绿假单胞菌总蛋白酶、弹性蛋白酶、绿脓菌素的分泌以及生物被膜的形成。推测栀子苷通过抑制铜绿假单胞菌群体感应而实现抗感染作用。
出处 《云南畜牧兽医》 2016年第1期3-5,共3页
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二级参考文献60

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