地特胰岛素与甘精胰岛素联合格列美脲对2型糖尿病患者血糖及体质量的影响

Influence of detemir insulin combined with glimepiride and glargine insulin combined with glimepiride on blood glucose and body weight of patients with type 2 diabetes mellitus

目的分析地特胰岛素与甘精胰岛素联合格列美脲对2型糖尿病患者血糖及体质量的影响。方法 160例2型糖尿病患者随机分为Det组和Gla组。Det组给予地特胰岛素联合格列美脲治疗,Gla组给予甘精胰岛素联合格列美脲治疗。治疗5个月后对2组患者血糖水平、体质量增加情况以及其他相关指标进行比较。结果治疗后,Det组的FC-P、2hcp、Au Ccp均明显高于Gla组,血糖稳定性比Gla组高;Det组的肥胖和超重患者比例及低血糖发生率低于Gla组(P<0.05);2组患者的FBG、2Hbg、Hb Alc数值,达标时间、胰岛素用量无显著差异。结论地特胰岛素联合格列美脲可减少对胰岛β细胞的损伤,有效稳定血糖,并能降低肥胖和低血糖的发生率,作用效果优于甘精胰岛素。

Objective To analyze the influence of detemir insulin combined with glimepiride and glargine insulin combined with glimepiride on blood glucose and body weight of patients with type 2 diabetes mellitus. Methods A total of 160 patients with type 2 diabetes mellitus were randomly divided into Det group and Gla group. The Det group was given detemir insulin combined with glimepiride treatment,while the Gla group was given glargine insulin combined with glimepiride treatment. Blood glucose levels,weight gain and other related indicators after 5 months of treatment were compared between two groups. Results After treatment,FC-P,2hcp,Au Cc-p of the Det group were significantly higher than those of the Gla group,and stability of blood glucose level was higher than that of the Gla group. The proportion of obese and overweight patients and the rate of hypoglycemia in the Det group were significantly lower than those of the Gla group（ P〈0. 05）.FBG,2Hbg,Hb Alc value,standard time,insulin dosage of patients in two groups were similar（ P〈0. 05）. Conclusion Detemir insulin combined with glimepiride can reduce pancreatic β cell damage,reduce the incidence rates of obese and hypoglycemia,and its effect is better than glargine insulin combined with glimepiride.