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The discovery of Qinghaosu(artemisinin) as an effective anti-malaria drug:A unique China story 被引量:5

The discovery of Qinghaosu(artemisinin) as an effective anti-malaria drug:A unique China story
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摘要 In a collective effort to find new drugs for killing the ma- laria parasites (plasmodium) that became resistant to the conventional drugs such as chloroquine, scientists in China not only rediscovered the anti-malaria effect of the Chinese herb Qinghao (Artemesia annua L.), but also isolated the single active ingredient Qinghaosu (artemisinin in English) in crystal form. They subsequently conducted very system- atic studies on the pharmacological properties of qinghaosu and its derivatives, and determined the unusual chemical structure of Qinghaosu. These anti-malaria drugs have saved countless lives, especially in the developing coun- tries. Due to her key role in achieving these remarkable discoveries, Prof. Youyou Tu was awarded the 2015 Nobel Prize in Physiology or Medicine "for her discoveries con- cerning a novel therapy against Malaria". Here I will try to tell this fascinating China story based on what have been recorded in the peer-reviewed papers that were published in Chinese or English and largely in journals published in China. In a collective effort to find new drugs for killing the malaria parasites(plasmodium)that became resistant to the conventional drugs such as chloroquine,scientists in China not only rediscovered the anti-malaria effect of the Chinese herb Qinghao(Artemesia annua L.),but also isolated the single active ingredient Qinghaosu(artemisinin in English)in crystal form.They subsequently conducted very system-
作者 Zengyi Chang
出处 《Science China(Life Sciences)》 SCIE CAS CSCD 2016年第1期81-88,共8页 中国科学(生命科学英文版)
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