摘要
Continuous flow has recently emerged as a powerful enabling technology that greatly improves many reactions' efficiency. Here, we apply the technology to intermolecular [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes by photoredox catalysis. An across-the-board improvement in the annulation's efficiency is noticed. Moreover, a gram-scale annulation is successfully demonstrated in continuous flow using a much lower catalyst loading.
Continuous flow has recently emerged as a powerful enabling technology that greatly improves many reactions＇ efficiency. Here, we apply the technology to intermolecular [4＋2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes by photoredox catalysis. An across-the-board improvement in the annulation＇s efficiency is noticed. Moreover, a gram-scale annulation is successfully demonstrated in continuous flow using a much lower catalyst loading.
基金
supported by the University of Arkansas
the Arkansas Bioscience Institute
the National Institutes of Health(P30 GM103450)from the National Institute of General Medical Sciences
the NSF Career Award(CHE-1255539)
