绝经前中重度乳腺增生症中他莫昔芬和托瑞米芬的应用

Application of tamoxifen and toremifene in moderate and severe premenopausal cyclomastopathy

目的观察在绝经前中重度乳腺增生症中他莫昔芬和托瑞米芬的应用情况。方法 300例绝经前中重度乳腺增生症患者,按照使用治疗药物的不同分为应用组与对照组,各150例。应用组使用托瑞米芬治疗;对照组使用他莫昔芬治疗。连续服用一段时间药物后比较两组患者的疗效。结果应用组总治疗有效率为98%,对照组总治疗有效率为86%,应用组优于对照组,差异有统计学意义(P<0.05)。结论在绝经前中重度乳腺增生症中使用托瑞米芬进行治疗,其效果比他莫昔芬更加明显,能够有效缓解患者的乳腺疼痛,提高治疗效果,保障患者的生活质量,临床可推广应用。

Objective To observe application of tamoxifen and toremifene in moderate and severe premenopansal eyelomastopathy. Methods A total of 300 patients with moderate and severe premenopaasal cyclomastopathy were divided by different medication into application group and control group, with 150 cases in each group. The application group received toremifene for treatment, and the control group received tamoxifen for treatment. Comparisons were made on curative effects between the two groups after a period of drug administration. Results Total effective rate was 98% in the application group and was 86% in the control group. The application grouphad better total effective rate than the control group, and the difference had statistical significance （P〈0.05）. Conclusion Implement of toremifene in moderate and severe premenopausal eyclomastopathy can provide much better effect than tamoxifen. It can remarkably relieve breast pain in patients, and improve curative effect and ensure quality of life. This method is worthy of clinical promotion and application.