新辅助化疗对局部进展期乳腺癌患者Cerb-2、Ki-67表达的影响

Influence of Neoadjuvant Chemotherapy on Cerb-2, Ki-67 Expression in Patients With Locally Advanced Breast Cancer

目的探讨局部进展期乳腺癌应用新辅助化疗对Cerb-2、Ki-67表达的影响。方法比较新辅助化疗前后40例局部进展期乳腺癌的Cerb-2、Ki-67表达情况。结果治疗前后Cerb-2表达差异无统计学意义(P>0.05),Ki-67表达差异有统计学意义(P<0.05)。结论局部进展期乳腺癌应用新辅助化疗可抑制Ki-67表达,但不影响Cerb-2表达。

Objective To investigate the influence of neoadjuvant chemotherapy on Cerb-2, Ki-67 expression in locally advanced breast cancer. Methods Compared Cerb-2, Ki-67 expression in 40 cases of locally advanced breast cancer before and after neoadjuvant chemotherapy. Results Cerb-2 expression had no significant difference before and after treatment（P〈0. 05）, Ki-67 expression had significantly different（P〈0. 05）. Conclusion Neoadjuvant chemotherapy can inhibit the expression of Ki-67 locally advanced breast cancer, but does not affect Cerb-2 expression.