匹多莫德治疗儿童反复呼吸道感染的临床疗效

Clinical Effect of Pi Do Maude in the Treatment of Children with Recurrent Respiratory Tract Infections

目的探讨匹多莫德治疗儿童反复呼吸道感染(RRI)的临床疗效。方法选取2012年6月至2014年12月辽宁省普兰店市中心医院儿科收治的194例RRI患儿作为研究对象,按随机数字表法将其分为观察组和对照组,各97例。对照组患儿给予常规治疗,观察组患儿在对照组基础上空腹服用匹多莫德口服液,比较两组患儿的临床疗效、临床症状体征消失时间、治疗前后免疫指标及不良反应发生情况。结果观察组患儿的总有效率明显高于对照组,差异有统计学意义(P<0.05);观察组患儿的退热、咳嗽缓解、扁桃体肿大消退、肺部啰音消失时间均明显短于对照组,差异均有统计学意义(均P<0.05);治疗后,观察组患儿的血清免疫球蛋白A(Ig A)、免疫球蛋白G(Ig G)及CD3+、CD4+、CD4+/CD8+T细胞均明显高于对照组,CD8+T细胞明显低于对照组,差异均有统计学意义(均P<0.05)。结论匹多莫德治疗儿童RRI临床疗效明显,可明显改善患儿的临床症状,提高免疫水平,且安全性高。

Objective To investigate the treatment of children with recurrent respiratory tract pidotimod clinical efficacy of infection（RRI） of.Methods From June 2012 to December 2014,194 patients with RRI were selected as the research object,according to the random number table method,which was divided into observation group and control group,each of 97 cases.The control group was given conventional treatment,the observation group in the control group on the basis of Pi do Maude oral liquid,compared the clinical efficacy of the two groups of children, clinical symptoms and signs disappeared time,the immune index and adverse reactions occurred in the treatment. Results Observation group with total efficiency was significantly higher than that of the control group,the difference is statistically significant（P 〈0.05）;observation group of children with fever,relieving cough,tonsil swelling subsided, pulmonary rales disappearance time were significantly shorter than that of the control group,differences were statistically significant（P 〈0.05）;after treatment observed groups of children serum immunoglobulin A（IGA）, immunoglobulin protein G（Ig G） and CD3＋,CD4＋,CD4＋ /CD8＋ T cell were significantly higher than those in the control group,CD8＋ T cells was significantly lower than that of the control group,differences were statistically significant（P 〈0.05）. Conclusion Pi do Maude in the treatment of children with RRI clinical efficacy significantly,can significantly improve the clinical symptoms,improve the immune level,and the safety is high.