叶酸对四氢叶酸还原酶基因突变高同型半胱氨酸水平的影响

Relationship of Folic Acid and Hyperhomocysteinemia in Hypertention with the Mutation of MTHFR Gene

目的研究叶酸对四氢叶酸还原酶基因C677T突变的高血压患者的高同型半胱氨酸血症的影响作用。方法随机收集100例亚甲基四氢叶酸还原酶基因C677T突变的高同型半胱氨酸水平的高血压患者,并按年龄、性别相匹配收集100例非亚甲基四氢叶酸还原酶基因突变的高同型半胱氨酸血症水平高血压患者,分别给以叶酸5毫克/天,共2个月。观察叶酸对还原酶基因突变的高血压患者的高同型半胱氨酸血症的影响作用。结果应用叶酸前后比较,还原酶基因突变及非基因突变两组,用叶酸后血同型半胱氨酸水平分别明显低于应用叶酸前的血同型半胱氨酸水平(P<0.01),但两组之间应用叶酸前后血同型半胱氨酸水平差别无统计学意义(P>0.05)。结论叶酸可以明显降低甲基四氢叶酸还原酶基因突变及无基因突变的高血压高同型半胱氨酸水平,两组血同型半胱氨酸水平的降低水平无明显差别。

Objective This study examined whether an elevation of folic acid treat hyperhomocysteinemia in the mutation of methylene tetrahydrofolate reductase（MTHFR） gene C677 T with hypertention. Methods The study consisted of 100 cases of hyperhomocysteinemia in the mutation of MTHFR gene with hypertention and 100 cases of hyperhomocysteinemia in the nonmutation of MTHFR Gene with hypertention. Folic acid was used for two months. The study observed difference of the total homocysteinemia of hypertention to folic acid intervention between the mutation of MTHFR gene and the nonmutation. Results The level of plasma total homocysteine in the mutation of MTHFR gene and the non-mutation after folic acid treating was significantly lower than before treating（P〈0.01）. The level of plasma total homocysteine between the mutation of MTHFR gene and the non-mutation was not significantly different before treating then after treating（P〈0.05）. Conclusion Folic acid was significantly effected in the MTHFR gene mutation of hyperhomocysteinemia hypertention patients as the non-mutation of the MTHFR gene ones.