白蛋白尿在SLE患者早期肾损害诊断中的价值

The Value of Albuminuria in the Diagnosis of Early Renal Impairment in Systemic Lupus Erythematosus Patients

目的探讨白蛋白尿在SLE患者早期肾损害诊断中的价值。方法收集2012年1月至2015年1月于我院诊断为SLE的患者,共计80例,将其作为研究组;对照组为同期来我院进行体检的健康人群80例。对比1研究组和对照组血尿素氮、尿肌酐。2研究组和对照组24 h尿白蛋白。结果 1研究组和对照组血尿素氮、尿肌酐分别为[(5.4±1.2)mmol/L、(12.4±3.5)mmol/d]、[(4.9±1.1)mmol/L、(12.1±4.2)mmol/d)],结果比较无差异(P>0.05)。2研究组和对照组24 h尿白蛋白分别为[(59.6±12.5)mg/L、(13.4±6.7)mg/L],差异比较具有统计学意义(P<0.05)。结论本次研究认为24 h尿白蛋白的测定有助于了解SLE患者是否有早期肾功能损害,从而根据患者的病情,给予针对性治疗。

Objective To explore the value of albuminuria in diagnosis of early renal impairment in systemic lupus erythematosus（SLE） patients. Methods Patients diagnosed with SLE from January 2012 to January 2015 in our hospital were collected, a total of 80 cases, as a study group; the control group was consisted of 80 healthy people in the same period for medical examination. Results 1The blood urea nitrogen and urinary creatinine of study group and control group were respectively [（5.4±1.2）mmol/L,（12.4±3.5）mmol/d）], [（4.9±1.1）mmol/L,（12.1±4.2）mmol/d）], which showed no differences（P〈0.05）. 224-hour urinary albumin of study group and control group were [（59.6±12.5）mg/L and（13.4±6.7）mg/L], which was statistically significant（P〈0.05）. Conclusion This study suggests that examination of albuminuria in patients with SLE helps to understand whether there is early renal dysfunction, therefore specific treatment can be given according to the patient＇s condition.