九味茶对高血压病合并空腹血糖受损患者胰岛素抵抗的临床研究

Effect of Jiuweicha on insulin resistance in patients with hypertension complicated by impaired fasting blood glucose: a clinical study

目的:观察九味茶对高血压病合并空腹血糖受损患者胰岛素抵抗的影响。方法:将101例高血压病合并空腹血糖受损患者随机分为两组,治疗组采用九味茶治疗加健康管理干预,对照组单纯采用健康管理干预。通过监测、血压、空腹血糖(FBG)、空腹胰岛素、血脂等指标,应用稳态模式评估公式HOMA-IR计算胰岛素抵抗指数,了解九味茶对代谢综合征高危人群胰岛素抵抗指数的影响。结果:治疗组治疗后收缩压、总胆固醇、空腹血糖均较治疗前下降(P<0.01),而对照组较前无明显下降(P>0.05);组间比较,治疗组收缩压、空腹血糖、低密度脂蛋白及HOMA-IR等指标均较对照组明显降低(P<0.05或P<0.01)。结论:高血压病合并空腹血糖受损患者在基础治疗同时加用九味茶治疗,可改善胰岛素抵抗。

Objective： To investigate the effect of Jiuweicha on insulin resistance in patients with hypertension complicated by impaired fasting blood glucose. Methods： A total of 101 patients with hypertension complicated by impaired fasting blood glucose were randomly divided into two groups. The patients in the treatment group were given Jiuweicha combined with health intervention,and those in the control group were given health intervention alone. The indicators such as blood pressure,fasting blood glucose（ FBG）,fasting insulin,and blood lipid were monitored,and the homeostasis model assessment of insulin resistance（ HOMA-IR） was applied to calculate insulin resistance index,so as to investigate the effect of Jiuweicha on insulin resistance index in the population at a high risk of metabolic syndrome. Results： The treatment group had significantly reduced systolic pressure,total cholesterol,and FBG after treatment（ P〈0. 01）,while these parameters showed no significant reductions after treatment in the control group（ P〉0. 05）;compared with the control group,the treatment group had significant reductions in systolic pressure,FBG,low-density lipoprotein,and HOMA-IR（ P〈0. 05 or P〈0. 01）. Conclusion： Jiuweicha in addition to basic treatment can be applied in patients with hypertension complicated by impaired fasting blood glucose,and can improve insulin resistance.