感染性心内膜炎抗生素治疗致红人综合征的案例分析

Antibiotic therapy induced red man syndrome in a patient with infective endocarditis

目的提醒临床重视输注抗生素所致的不良反应。方法分析1例感染性心内膜炎患者应用万古霉素治疗,用药时面部和双上肢出现红色斑丘疹伴皮肤瘙痒,经抗过敏及更换抗生素后皮疹消退,治疗1个月后停用抗生素,停药期间再次出现面部、四肢、躯干红色斑丘疹。结果和结论患者再次抗过敏治疗后全身皮肤基本恢复正常。预防红人综合征的措施主要是控制输注速度,必要时可预防性用药。

Objective To remind the clinic to pay attention to the adverse drug reaction caused by the infusion of antibiotics. Methods Retrospective analysis of a case of one patient with infective endocarditis who was treated with vancomycin. Red rash with pruritus occurred on the face and upper limbs on the next day. The rash disappeared after anti- allergy and replacement of antibiotics. After one month treatment by antibiotics,red rash appeared again on face,limbs and chest during withdrawal.Results After anti- allergy treatment,patient was returned to normal.Measures to prevent the red man syndrome is mainly to control the infusion rate,if necessary,preventive medication given.