阿德福韦酯致低磷性骨软化症1例

Case report of hypophosphatemic osteomalacia induced by adefovir dipivoxil

目的提示临床重视阿德福韦酯导致的低磷性骨软化症。方法回顾性分析1例乙型肝炎患者服用阿德福韦酯后导致低磷性骨软化症的临床资料。结果患者服用阿德福韦酯1日10mg,29个月开始出现进行性加重的胸痛,生化、骨密度检测及影像资料显示其出现低磷性骨软化症。结论阿德福韦酯可致低磷性骨软化症,临床应用时应注意定期复查血清磷。

Objective To report and analyze the adverse drug reaction induced by adefovir dipivoxil which caused hypophosphatemic osteomalacia,and to promote the rational drug use in clinic.Methods The clinical data of 1case of adefovir dipivoxil-induced hypophosphatemic osteomalacia was analyzed retrospectively.Results The patient received oral adefovir dipivoxil 10 mg once daily.He experienced progressive bone pain in 29 th month,and adefovir dipivoxil induced hypophosphatemic osteomalacia was showed by laboratory examination,bone density examinations and imaging examinations.Conclusion Adefovir dipivoxil could induced hypophosphatemic osteomalacia,so serum phosphate level should be periodically tested.