三种保肝药治疗中晚期肝癌介入化疗栓塞后肝损伤的疗效比较

Comparative Study of Three Different Hepatinicaonhepatocellular Carcinoma with Transcatheter Arterial Chemoembolization-induced Liver Injury

目的探讨三种不同保肝药物,对原发性肝癌患者肝动脉介入化疗栓塞治疗后肝功能恢复的疗效比较,为临床治疗提供合理建议。方法对2000年1月-2014年12月,诊断为中晚期原发性肝癌并行介入化疗栓塞治疗的病例126份进行分析,观察保肝药A=抗炎类、B=膜稳定类、C=解毒类治疗后肝功能的指标及临床疗效的差异。结果三组药物治疗后第3天,患者血清ALT、AST水平见存在差异,B组高于A组和C组,但TBIL、术后第14天三种肝功能指标,及临床症状恢复均无统计学意义。结论原发性肝癌肝动脉介入化疗栓塞治疗相关性肝损伤,抗炎类及解毒类护肝药对早期转氨酶的恢复功能优于膜稳定类护肝药,但对改善肝功能损伤的长期疗效无差异。

Objective To explore the effectiveness of three different hepatinicatreatment and the recovery of hepatic function in the treatment of transcatheter arterial chemoembolization（ TACE）- induced Liver Injury in onhepatocellular Carcinoma（ HCC）. Methods To observe the hepatic function and clinical effects,126 cases which were diagnosed as mid- advanced HCC with liver injure induced by TACE were chosen,and givenone of three hepatinica treatment： A =Anti- inflammatory,B = membrane system stabilizing detoxification（ MSSD）,C = detoxificationfrom Jan 2000 to Dem2014. Results The levels of ALT and AST on the third day after TACE operation were different significantly,those of B group were higher than A and C group. However,there were no significant on clinical features,TBIL,and on day 14.Conclusions Anti- inflammatory and detoxification hepatinica was superior to MSSD hepatinica on recovery of hepatic function on early phage of TACE- induced liver injury in HCC.