肝素结合蛋白与降钙素原检测在脓毒症患者预后评估中的作用比较

Comparison of heparin binding protein and procalcitonin in the evaluation of prognosis of patients with sepsis

目的：比较肝素结合蛋白（HBP）与降钙素原（PCT）检测在重症医学科脓毒症患者预后的评估作用。方法选择脓毒症患者80例，根据病情程度分为一般脓毒症组（n ＝31）、严重脓毒症组（n ＝29）和死亡组（n ＝20），比较三组 HBP 和 PCT 的差异。结果与一般脓毒症组 HBP 和 PCT[（3．91±0．36）ng／mL 和（1．26±0．35）ng／mL）]相比，严重脓毒症组 PCT[（11．81±0．54）ng／mL]明显升高（F ＝2777．87，P ＝0．000）；死亡组 HBP 和 PCT[（15．28±1．21）ng／mL 和（36．68±0．36）ng／mL）]与一般脓毒症组和严重脓毒症组相比明显增高（F ＝49789．02，P ＝0．000）。结论PCT 在各组中的敏感度明显高于 HBP，作为判断脓毒血症预后的指标 PCT 的效果更佳。

Objective To compare heparin binding protein （HBP）and procalcitonin（PCT）in the evalua-tion of in prognosis of patients with sepsis in ICU.Methods 80 sepsis patients were selected.According to the sever-ity of the disease,they were divided into general sepsis group （n =31）,severe sepsis group （n =29）and death group （n =20）.The differences of HBP and PCT in three groups were compared.Results Compared with HBP and PCT in the general sepsis group[（3.91 ±0.36）ng/mL,（1.26 ±0.35）ng/mL）],PCT of the severe sepsis group （11.81 ± 0.54）ng/mL was significantly increased（F =2 777.87,P =0.000）;HBP and PCT of the death group[（15.28 ± 1.21 ）ng/mL,（36.68 ±0.36）ng/mL）]were significantly increased compared with the general sepsis and severe sep-sis groups （F =49 789.02,P =0.000）.Conclusion The sensitivity of PCT was significantly higher than HBP in the groups,PCT was better in judging the prognosis of sepsis.