右美托咪定对老年人术后认知功能的影响及机制的研究

Research on the influence of dexmedetomidine on elderly postoperative cognitive function and its mechanism

目的探讨右美托咪定对老年患者术后早期认知功能的影响。方法收集我院2013年1月至2014年8月普外科老年手术患者126例,随机分为对照组和治疗组各63例,麻醉诱导后对照组给予泵注生理盐水,治疗组给予右美托咪定泵注处理,术后采用简易智力检查法(MMSE)对术后1、3、7天两组患者认知功能进行评分,对两组患者术后早期认知功能进行对比分析。结果术后1、3、7天观察组MMSE评分明显高于对照组,两组比较差异有统计学意义(P<0.05);术后1天S100β、NSE浓度检测,观察组含量低于对照组,两组比较差异有统计学意义(P<0.05)。结论老年手术患者中使用右美托咪定可有效改善早期认知功能,值得在临床上推广使用。

Objective This aimed to investigate the effects of dexmedetomidine on postoperative cognitive function of elderly patients. Methods 126 cases of elderly patients,hospitalized in surgery department of our hospital during January 2013 and August 2014,were randomly divided into a control group and treatment group,63 cases in each group. After induction of anesthesia,control group received saline infusion,the treatment group received dexmedetomidine infusion process,simple intelligence test method（ MMSE） was used to assessed the cognitive function score of the two groups after 1,3,7 days,and them analyzed the cognitive function.Results 1,3 and 7 days after the treatment,MMSE score was significantly higher in the observation group compared with control group,the difference was statistically significant（ P〈 0. 05）. One day post the operation S100β and NSE concentrations detected in the observation group were less than the control group,the differences were statistically significant（ P〈 0. 05）. Conclusions The application of dexmedetomidine in elderly patients during surgery can improve cognitive function and should be introduced in clinical practice.