Neuropilin-I与人脑胶质瘤关系的研究进展

Progress on the relationship between neuropilin-l and human brain glioma

人脑胶质瘤是最常见的中枢神经系统肿瘤,具有浸润性强、易复发及预后不良等特点。在脑胶质瘤细胞中,神经纤毛蛋白-1(Neuropilin-1,NRP-1)表达水平异常升高,与肿瘤增殖、浸润及血管形成等过程关系密切。作为一种膜蛋白,NRP-1可以作为共受体同信号素3、血管内皮生长因子等多种配体结合并强化信号的传导。目前,靶向NRP-1诊治脑胶质瘤已成为研究热点。无论是NRP-1单克隆抗体还是C末端法则多肽均展现了抑制胶质瘤生长浸润的能力。随着对NRP-1结构及信号通路分子机制的进一步明确,靶向NRP-1进行分子水平诊治将成为改善胶质瘤患者预后的重要手段。

Human brain glioma is the most common tumor in central nervous system,characterized by strong invasion, easy relapse and poor prognosis. In glioma cells, over expression of neuropilin-1（NRP-1） is closely related to the processes of proliferation, invasion and neovascularization. As a membrane protein, NRP-1 acts as a coreceptor for a number of extracellular ligands including semaphorin 3and vascular endothelial growth factor, and enhances signal transduction. Nowadays, target NRP- 1 on diagnosing and treating brain glioma has been a research hotspot. Proliferation and invasion of glioma can be inhibited by either NRP-1 monoclonal antibody or Cend rule peptide. It could be proper to predict that further research on NRP-1 structure and molecular mechanisms of signaling pathway will provide an important measure for improving the glioma prognosis by diagnosing and treating it with target NRP-1.