降钙素原对社区获得性肺炎和肺结核的临床鉴别意义

The clinical identification value of procalcitonin for community acquired pneumonia and tuberculosis

目的探讨血清降钙素原(PCT)对鉴别诊断社区获得性肺炎与肺结核的临床意义。方法收集2012年7月—2014年11月湖南省中医药研究院附属医院同期入院诊断为社区获得性肺炎患者(肺炎组)40例及肺结核患者(结核组)42例的血清标本,并以50例门诊健康体检者血清作为对照组。分析比较各组患者的血清降钙素原水平。结果肺炎组血清PCT>0.5 ng/m L的阳性病例共31例,明显高于结核组(P<0.05);肺炎组的测定结果主要分布在阳性组(PCT>0.5 ng/m L),阳性例数较其他两组显著升高(P<0.05);肺炎组PCT、CRP、WBC明显高于其他两组(P<0.05);肺炎组患者PCT水平与CURB-65评分呈现正相关的关系(r=0.95)。结论血清降钙素原的测定对鉴别诊断社区获得性肺炎和肺结核具有重要的临床意义。

Objective To explore the clinical identification value of procalcitonin （PCT） for community acquired pneumonia and tuberculosis. Methods We collected serum samples from 40 cases of community acquired pneumonia （pneumonia group）, 42 cases of tuberculosis （TB group） and 50 cases of outpatient health check-up （control group）, who were diagnosed in the Institute of Chinese Medicine Affiliated Hospital of Hunan from July 2012 to November 2014. The PCT level of patients would be analyzed and compared. Results The positive cases （31, PCT〉0.5 ng/mL） of pneumonia group were significantly higher than TB group （P〈0.5） ;Determination results of pneumonia group were mainly distributed in the positive group （PCT〉0.5ng/mL） , the positive cases significantly more than the other two groups （P〈0.05） ;The PCT, CRP, WBC of pneumonia group were significantly higher than that of other two groups （P〈0.05） ;The PCT level had a positive correlation with CURB-65 scores in pneumonia group（r=0.95）. Conclusion The serum procalcitonin are important clinical implications for the differential diagnosis of community acquired pneumonia and tuberculosis.