老年代谢综合征各组分及RBP4与糖尿病患病的关系

Association of components in metabolic syndrome and RBP4 with type 2 diabetes mellitus in elderly

目的探讨代谢综合征(MS)各组分以及视黄醇结合蛋白4(RBP4)与MS患者2型糖尿病(T2DM)患病情况的关系。方法将202例老年MS患者依据是否合并T2DM分为DM组(123例)和NDM组(79例)。并选取35例健康者为对照组。ELISA测定血清RBP4,同时测定血糖、血压及血脂等指标。比较各组的一般情况、血脂、糖代谢等生化指标和RBP4的差异。并通过Logistic回归筛选T2DM的独立危险因素。结果 DM组空腹血糖(FPG)、腰围(WC)、收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、RBP4,均高于NDM组(P<0.01)。Logistic回归分析结果显示MS患者并发T2DM的危险因素包括WC、SBP、TG、RBP4。结论中心性肥胖、血脂异常、高血压以及RBP4可能参与了MS合并T2DM的发生与发展。

Objective To study the association of components in metabolic syndrome （MS）and the serum retinol binding protein 4 （RBP4） with type 2 diabetes mellitus （T2DM）. Methods A total of 202 aged patients with MS were divided by whether with T2DM into two groups： MS with T2DM （DM, n=-123）and MS without T2DM （NDM, n=79）, and control group included 35 healthy subjects. Serum RBP4 level was measured by ELISA. The indicators of glucose, blood pressure, and blood lipids were also determined. General condition, lipid profiles, glycometabolism parameters, other serum biochemical parameters and RBP4 were detected and compared. And then, logistic regression analysis was used to find the independent risk factors for T2DM. Results The levels of FPG, WC, SBP, DBP, TG, RBP4 in MS patients with T2DM were significantly higher, compared with patients without T2DM （P〈0.01）. Logistic regression showed WC, SBP, TG and RBP4 were independent risk factors for MS patients with T2DM. Conclusion Central obesity, dyslipidemia, hypertension and RBP4 may participate in the occurrence and development of MS complicating with T2DM.