摘要
目的:观察消瘰合剂Ⅱ号在颈淋巴结核治疗过程中的作用并探讨其作用机制。方法:将60例入选患者随机分为中西药组和西药对照组,每组30例。对照组采用正规西药化疗方案,中西药组在此基础上加用消瘰合剂Ⅱ号,通过观察症状变化、淋巴结吸收情况、窦道愈合情况、细胞因子(TNF-α、IFN-γ)变化以及患者不良反应、耐受性、依从性等情况,比较两组疗效及毒副反应发生率。结果:中西药组有效率较对照组高,差异具有统计学意义(P<0.05),且中西药组的毒副反应发生例数少于对照组,但差异无统计学意义(P>0.05);经过治疗,中西药组肿瘤坏死因子(TNF-α)表达水平明显降低(P<0.05),IFN-γ表达水平明显升高(P<0.05)。结论:消瘰合剂Ⅱ号能够通过提高机体免疫力促进颈淋巴结核患者的窦道愈合,减轻药物副反应,减毒增效。
Objective： To observe the effect of Xiaoluo Mixture Ⅱ in cervical lymph nodes tuberculosis and explore the mechanism. Methods： 60 patients were randomly divided into two groups： Chinese medicine group and control group,with 30 in each. Both groups were given routine anti- TB treatment and Xiaoluo Mixture Ⅱ was added in Chinese medicine group. Analyzing the the effect and mechanism of Xiaoluo Mixture Ⅱ on lymph nodes by observing the change of symptom,size of lymph nodes,cytokines（ TNF- α,IFN- γ）,side- effect,tolerance and compliance. Results： The total effective rate of Chinese medicine group were all superior to control group in statistics. The side- effect of Chinese medicine was less than control group,but the two groups have no statistical difference（ P 0. 05）. TNF- α level in Chinese medicine group was significantly lower than that in control group（ P 0. 05）,IFN- γ level in Chinese medicine group were significantly higher than that in control group（ P 0. 05）. Conclusion： Xiaoluo Mixture Ⅱ has the function of increasing efficacy and deceasing toxicity through improving immunity and reducing the adverse drug reaction.
出处
《中国中医药科技》
CAS
2016年第1期16-18,共3页
Chinese Journal of Traditional Medical Science and Technology
基金
浙江省中医药科技计划项目(2011ZB107)
