摘要
文章对补充不同叶酸剂量的培美曲塞方案疗效和安全性进行分析，重点关注高剂量叶酸补充对培美曲塞疗效和毒性影响，探讨培美曲塞初始治疗方案中叶酸首次给药时间，以及同型半胱氨酸水平能否作为一个理想的生物指标预测培美曲塞相关血液性毒性。
This review analyzed the effect of folic acid on pemetrexed efficacy and toxicity, especially high-does folic acid supplementation. The optimal duration for supplementation prior to the first dose of pemetrexed has not been defined. The review also explored whether total plasma homocysteine levels can be as a marker to predict and avoid toxicity from pemetrexed therapy.
出处
《肿瘤研究与临床》
CAS
2016年第1期61-63,共3页
Cancer Research and Clinic
