摘要
目的观察结直肠腺瘤患者血脂水平变化,并探讨其意义。方法结直肠腺瘤患者102例(腺瘤组),结直肠镜和组织学检查正常者122例(对照组),采用全自动生物化学检测仪检测各组血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)。结果腺瘤组TC、TG、HDL-C、LDL-C水平分别为(5.04±0.48)、(1.87±0.38)、(1.05±0.23)、(3.25±0.26)mmol/L,对照组分别为(4.89±0.36)、(1.45±0.54)、(1.14±0.64)、(3.09±0.46)mmol/L,两组TC、TG、LDL-C水平比较,P均<0.05。腺瘤组非进展期者TC、TG、HDL-C、LDL-C水平分别为(4.99±0.42)、(1.80±0.34)、(1.01±0.33)、(3.21±0.25)mmol/L,进展期者分别为(5.13±0.50)、(2.00±0.41)、(1.00±0.40)、(3.32±0.27)mmol/L,两者TG、LDL-C水平比较,P均<0.05。腺瘤组左半结肠+直肠者TC、TG、HDL-C、LDL-C水平分别为(5.10±0.46)、(1.94±0.36)、(0.99±0.34)、(3.26±0.25)mmol/L,右半结肠者分别为(4.85±0.52)、(1.73±0.40)、(1.08±0.24)、(3.23±0.27)mmol/L,两组TC、TG水平比较,P均<0.05。结论结直肠腺瘤患者血脂水平异常,其与结直肠腺瘤的发生有密切的联系。
Objective To observe the changes in levels of serum lipids in patients with colorectal adenomas ( CRAs), and to investigate its significance. Methods We selected 102 patients with CRAs ( CRAs group) and 122 healthy con- trois with normal colorectal endoscopic and histological examination (control group). The levels of serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were respectively detected by automatic biochemical detector. Results The levels of TC, TG, HDL-C and LDL-C in the CRAs group were (5.04 ±0.48), ( 1.87 ± 0.38 ), ( 1.05 ± 0.23 ) and (3.25 ± 0.26) mmol/L, respectively; and (4.89 ± 0.36), ( 1.45 ±0.54), ( 1.14 ± 0.64) and (3.09± 0.46) mmol/L in the control group. Significant difference was found in the levels of TC, TG and LDL-C between the two groups ( all P 〈 0.05 ). The levels of TC, TG, HDL-C and LDL- C of CRAs patients in advanced stage were respectively (4.99± 0.42), ( 1.80 ± 0.34), ( 1.01 ± 0.33 ) and (3.21 ± 0.25) mmol/L, and those in non-advanced stage were respectively (5.13±0.50), (2.00 20.41), (1.00 20.40) and (3.32 ±0.27) mmol/L; the levels of TG and LDL-C of CRAs patients in advanced stage were significantly increased as compared with those in non-advanced stage (all P 〈 0.05). In addition, the levels of TC, TG, HDL-C and LDL-C in the left-site CRAs patients were respectively (5.10 ± 0.46), ( 1.94 ± 0.36), (0.99 ± 0.34 ) and ( 3.26 ± 0.25 ) mmol/L, those were (4.85 ± 0.52), ( 1.73 ± 0.40), ( 1.08 ± 0.24) and (3.23 ± 0.27) mmol/L in the right-site CRAs patients, respectively; the levels of TC and TG in the left-site CRAs patients were significantly increased as compared with those of the right-site CRAs patients (all P 〈 0.05 ). Conclusion The serum lipid levels in patients with CRAs were abnormal, which were closely related with the occurrence of CRAs.
出处
《山东医药》
CAS
北大核心
2016年第3期37-39,共3页
Shandong Medical Journal
基金
河南省创新型科技团队基金资助项目(C20150009)
关键词
结直肠腺瘤
血脂异常
总胆固醇
甘油三酯
高密度脂蛋白
低密度脂蛋白
colorectal adenoma
dyslipidemia
total cholesterol
triglyceride
high-density lipoprotein
low-density lipoprotein