合理选择适合中国2型糖尿病患者的降糖方案

Regimen for optimizing glycaemic control in Chinese patients with type 2 diabetes

近年来中国T2DM人群不断增加。中国人群日常饮食结构及胰岛β细胞早相分泌障碍的特征,决定了中国T2DM患者餐后血糖升高突出的现状。餐后血糖增高是微血管、大血管并发症的独立危险因素,高餐时胰岛素比例的预混胰岛素能有效控制餐后血糖。胰岛素类似物较人胰岛素更为贴近胰岛素的自然分泌曲线。双时相门冬胰岛素50能更好地降低餐后血糖峰值、降低低血糖风险,且注射灵活,更适合中国T2DM患者血糖的管理。

Prevalence of type 2 diabetes mellitus（T2DM）in China has increased rapidly.Traditional Chinese diet and early phase defect in insulin secretion are two major reasons of high postprandial glucose（PPG）in Chinese T2 DM patients.Elevated PPG is an independent risk factor for micro-and macro-vascular complications.Premix insulins with high proportion of prandial insulin are used to improve PPG control.Compared to human insulin,insulin analogues resemble the physiological insulin response more closely.Biphasic insulin aspart 50 provides better efficacy and safety profiles,allows more flexibility in the timing of injection,and appears to be a suitable glycaemic control option for Chinese patients with T2 DM.