纳米凝胶载体系统的研究进展

Research Progress in Nanogel Carrier Systems

纳米凝胶具有粒径小、血液循环时间长、生物相容性好、生物可降解、载药量高等优点。通常用于制备纳米凝胶的载体材料有聚丙烯酸及聚丙烯酰胺类、普朗尼克类、聚多糖类高分子材料及其衍生物,可通过基于氨基的交联、"click"反应交联、物理交联、光交联、多相单体聚合等方法形成纳米凝胶。纳米凝胶作为一种理想的新型给药系统在化疗药物、蛋白类药物及基因的递送等方面显示出广阔的应用前景。笔者参考近期相关文献,对纳米凝胶的常用载体材料,制备方法及应用进行整理与总结。

Nanogels combine the advantages of hydrogels and nanoparticles, such as small particle size, prolonged blood circulation time, biocompatibility, biodegradation and high drug loading. Common carrier materials is used for the preparation of nanogels include polyacrylic acid, polyacrylamide, pluronic, polysaccharide and their derivates. They can be cross-linked based on amine reaction, ＂click＂ chemistry, photo-induced cross-linking, physical cross-linking or heterogeneous polymerization of monomers to form nanogel carrier systems. Nanogels, as ideal and novel drug delivery systems, have great promise in the delivery of chemotherapeutic drugs, proteins and genes. The carrier materials, preparation methods and applications of nanogels were reviewed based on relevant articles published in recent years.