替加环素中钯残留的微波消解-ICP-MS法测定

Determination of Palladium in Tigecycline by Microwave Digestion-ICP-MS

建立了电感耦合等离子体质谱法（ICP-MS）测定替加环素中残留的钯。采用微波消解处理样品,以ICP-MS法测定。钯在10~250 ng/ml浓度范围内线性关系良好,检测限为3.07 ng/g。方法平均回收率为88.8%~99.2%,RSD为0.9%~1.2%。

An inductive coupled plasma mass spectrometry（ICP-MS） method was established for the determination of palladium residue in tigecycline. The samples were pretreated by microwave digestion technology and determined by ICP-MS. It was linear for palladium in the concentration range of 10 — 250 ng/ml, with the limit of detection of 3.07 ng/g. The mean recoveries were 88.8% — 99.2%, with RSDs of 0.9% — 1.2%.