IVIM-DWI参数与乳腺浸润性导管癌预后因子ER、c-erbB-2的相关性

Correlation between the IVIM-derived parameters and prognostic biomarkers of ER and c-erb B-2 in breast invasive ductal carcinoma

目的:探讨体素内不相关运动扩散加权成像(IVIM-DWI)参数与乳腺浸润性导管癌预后因子雌激素受体(ER)、人类表皮生长因子受体(c-erb B-2)的相关性。方法:回顾性分析42例乳腺浸润性导管癌患者的IVIM-DWI图像和免疫组织化学染色结果。采用Kruskal-Wallis检验及Spearman等级相关分析比较不同ER、c-erb B-2表达强度组间IVIM-DWI参数f值、D值、D*值的差异及其相关性。结果:不同ER表达强度组间f值、D*值存在统计学差异(P<0.05);且f值、D*值与ER表达强度存在弱负相关(r=-0.334,r=-0.281;均P<0.05)。不同c-erb B-2表达强度组间f值、D值、D*值差异均无统计学意义(P>0.05)且与c-erb B-2表达强度无明显相关性(P>0.05)。结论:f值、D*值与不同ER表达强度组间存在相关性,可为乳腺浸润性导管癌患者提供有价值的组织学信息。

Objective To investigate the possible correlations between IVIM-derived parameters of breast invasive ductal carcinoma and prognostic biomarkers of ER, c-erb B-2. Methods Data of immunohistochemistry and the images of 42 patients with breast invasive ductal carcinoma were retrospectively analyzed. The values of f,D and D＊and the intensity of ER, c-erb B-2 expression were compared with Kruskal-Wallis test. The relationships between them were investigated by Spearman rank correlation. Results There were difference of f, D＊values among different intensity of ER expression（P 〈0.05） and the values of f and D＊ were negatively correlated weakly with the ER expression（r =-0.334, r =-0.281; P 〈0.05）. No significantly difference was found between IVIM-derived parameters and the prognostic factors of c-erb B-2（P 〈0.05）, and there was no correlation betweenthem（P 〈0.05）. Conclusion There is correlation between the values of f and D＊and the intensity of ER expression. It reflects that IVIM-DWI might provide helpful tissue characterization parameters.