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合成生物学研究和应用的生物安全问题 被引量:12

Biosafety issue on researches and applications of Synthetic Biology
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摘要 合成生物学指基于系统生物学的遗传工程,人工设计与合成新的生物元件和生物系统。本文简述合成生物学的发展及其可能造成的环境、公众健康安全问题及伦理问题。借鉴欧美等国家在合成生物学发展及管理方面的经验,提出中国应加强合成生物学研究和应用的风险评估、完善监督和管理体系、强化生物安全和生物伦理教育、推动与国际社会的交流和合作等。 Synthetic biology refers to artificial design and construction of genetic parts and biology systems, which is based on genetic engineering of systematic biology. We firstly review the development status of synthetic biology, the ethical issue, and the safety issue it may cause to the environment and public health. Europe and America support the development of synthetic biology while continuing to improve their management mechanisms. In view of the fact that domestic synthetic biology is still in its infancy, we recommend some corresponding countermeasures in the development of systematic biology based on the lessons from others countries, including strengthening risk assessment in the application and research of synthetic biology, improving supervision and management systems, strengthening biosafety and bioethics education, and promoting exchanges with the international community.
出处 《科技导报》 CAS CSCD 北大核心 2016年第2期307-312,共6页 Science & Technology Review
基金 武汉市新发传染病与生物安全重点实验室资助项目(201261638501) 国家卫生和计划生育委员会公益性行业科研专项(201302006)
关键词 合成生物学 生物安全 生物伦理 synthetic biology biosafety bioethics
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  • 1Hobom B. Gene surgery: on the threshold of synthetic biology. Med Klin, 1980, 75(24): 834-41.
  • 2Cello J, Paul AV, Wimmer E. Chemical synthesis of poliovirus cDNA: generation or infectious virus in the absence of natural template. Science, 2002, 297(5583): 1016-8.
  • 3Chan LY, Kosuri S, Endy D. Refactoring bacteriophage T7. Mol Syst Biol, 2005, 1:2005.0018.
  • 4Posfai G, Plunkett G, Feher T, et al. Emergent properties of reduced-genome Escherichia coli. Science, 2006, 312(5776): 1044-6.
  • 5Gibson DG, Benders GA, Andrews-Pfannkoch C, et al. Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome. Science, 2008, 319(5867): 1215-20.
  • 6Gibson DG, Glass JI, Lartigue C, et al. Creation of a bacterial cell controlled by a chemically synthesized genome. Science, 2010, 329(5987): 52-6.
  • 7Gardner TS, Cantor CR, Collins JJ. Construction of a genetic toggle switch in Escherichia coli. Nature, 2000, 403(6767): 339-42.
  • 8Isaacs F J, Dwyer D J, Collins JJ. RNA synthetic biology. Nat Biotechnol, 2006, 24:545-54.
  • 9Friedland AE, Lu TK, Wang X, et al. Synthetic gene networks that count. Science, 2009, 324:1199-202.
  • 10Stricker J, Cookson S, Bennett MR, et al. A fast, robust and tunable synthetic gene oscillator. Nature, 2008, 456(7221): 516-9.

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