头针治疗缺血性中风的机制研究进展

Development of Researches on Scalp Acupuncture for Ischemic Stroke

就近年来头针治疗缺血性中风的机制研究进行总结,认为目前的研究主要集中在头针改善脑循环,促进脑能量代谢,调节神经生长因子,促进神经干细胞增殖分化,降低兴奋性氨基酸毒性,调节脑血管炎性反应,抗自由基损伤,抑制细胞凋亡等方面,但尚缺乏上述机制的分子调节研究。因此,今后需多学科交叉,从分子调节角度深入研究,可望能深刻阐释头针治疗缺血性中风的机制。

Ischemic stroke is one of the commonly met diseases in clinical practice nowadays.Acupuncture therapy is widly used in the treatment of sequela of ischemic stroke in China and its mechanisms have been extensively studied in recent years.In the present paper,the authors focus on the development of studies on the mechanism of scalp acupuncture therapy in the treatment of ischemic stroke.Results indicate that scalp acupuncture intervention can 1）improve cerebral blood circulation to promote regional energy metabolism,2）up-regulate expression of glial cell-line derived neurotrophic factor（GDNF）,etc.,possibly promoting proliferation and differentiation of neural stem cells in the focal cerebral cortex and hippocampus,3）reduce contents of excitatory amino acid and increase level of gamma-aminobutyric acid（GABA）to lower neurogenic toxicity,and relieve cerebral injury,4）ease cerebral vascular immunoinflammatory reactions,5）regulate blood lipid metabolism to resist cerebral free radical damage,and 6）inhibit cerebral cortical apoptosis.However,these results only revealed very limited intrinsic mechanisms of scalp acupuncture in improving ischemic stroke.Further studies using comprehensive techniques of multi-disciplines as molecular biology,electrophysiology,etc.are definitely needed.