肝硬化肝脏部分切除术后肝再生的研究进展

Cirrhotic liver regeneration after partial hepatectomy

肝脏是具有强大再生能力的器官,其再生机制十分复杂.肝再生是一个受多种调控因子参与的高度协调的过程,同时再生的过程中受多种因素影响.肝硬化是影响肝再生的一个重要因素,肝硬化肝脏的再生功能明显受损.我国是肝硬化后肝癌发生的高发国家,进一步明确肝硬化患者术后肝再生受损的机制,对于改善此类患者的预后具有深远意义.目前,国内外对于肝硬化肝脏的再生调控机制的研究多围绕调节肝再生的信号通路及各种相关细胞因子等方面展开,本文就此类文献的观点作一综述.

The liver is an organ with strong regenerative ability, and its regenerative mechanism is very complex. The liver regenerative process isregulated by various kinds of factors, which coordinate highly, and is also influenced by many other factors. liver cirrhosis is an liver regeneration, Studies have shown that important factor affecting and cirrhotic liver shows significantly impaired regenerative function. Liver cancer frequently occurs following cirrhosis in China, so further definition of the regenerative mechanism after partial hepatectomy in these patients has far-reaching significance for improving their prognosis. Nowadays, most studies on.the regulatory mechanism of cirrhotic li;~ef regeneration on focused on different signaling pathways and various related cytokines. This review summarizes the findings of these studies