肠道微生态与胰腺炎的研究进展

Intestinal microecology and pancreatitis

肠道共生微生物与人体相互依存而生,构成人体肠道微生态系统.共生微生物通过病原相关分子模式(pathogen-associated molecular pattern,PAMPs)与宿主模式识别受体相互作用,在多种疾病中发挥重要作用.PAMPs与损伤相关分子模式(damage-associated molecular pattern,DAMPs)均不同程度的参与了胰腺炎病程进展.肠道微生态在胰腺炎病程中具有重要作用.急性胰腺炎早期即存在肠道屏障功能障碍及肠道细菌易位,增加了胰腺感染和死亡的几率.肠道微生物感染与慢性胰腺炎的发生发展有关,并可能通过分子模拟等机制诱发自身免疫性胰腺炎(autoimmune pancreatiti,AIP).深入研究肠道微生态及其与胰腺炎的关系,将为胰腺炎的诊断及防治提供指导和方向.

The intestinal symbiotic microbes and the human body depend on each other to form the intestinal microecology system of the human body. Symbiotic microorganisms play an important role in many diseases through theinteraction between pathogens and host pattern recognition receptors. Pathogen-associated molecular pattern （PAMPs） and damage- associated molecular patterns （DAMPs） are involved in the progression of pancreatitis. Intestinal microecology plays an important role in the pathogenesis of pancreatitis. Acute pancreatitis, which is associated with intestinal barrier dysfunction and bacterial translocation, increases the risk of pancreatic infection and death. Infection with intestinal bacteria is related to the development of chronic pancreatitis, and it may induce autoimmune pancreatitis （AIP） by molecular modeling. Understanding the relationship between intestinal microecology and pancreatitis will provide guidance and direction for the diagnosis and treatment of pancreatitis.