慢性乙型肝炎患者临床指标与肝脏纤维化程度关系及明显肝纤维化危险因素的Logistic回归分析

Relationship between clinical parameters and degree of liver fibrosis and risk factors for significant liver fibrosis in patients with chronic hepatitis B: A Logistic regression analysis

目的:探讨慢性乙型病毒性肝炎(chronic hepatitis B,CHB)患者肝脏纤维化分期与临床指标的关系,并分析CHB患者明显肝纤维化的危险因素.方法:选择2012-01/2015-07在昆明医科大学第二附属医院消化内科住院接受肝活检的76例C H B患者为研究对象.记录患者的性别、年龄,收集所有患者的全血细胞计数,包括白细胞、血红蛋白(hemoglobin,HB)、血小板(platelet,PLT)、红细胞分布宽度(red blood cell distribution width,RDW)、平均血小板体积(mean platelet volume,MPV)以及白蛋白(albumin,ALB)、球蛋白(globinemia,GLO)、丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、碱性磷酸酶(alkaline phosphatase,ALP),γ-谷氨酰转移酶(gamma-glutamyl transpeptidase,GGT)、总胆红素(total bilirubin,TB)、凝血酶原时间(prothrombin time,PT)、血清HBV DNA.分析各个指标与CHB患者肝纤维化分期的关系及明显肝纤维化的危险因素.结果:随着肝纤维化程度加重,白细胞计数、HB、PLT、ALB逐渐降低,而RDW、GLO、AST、PT、GGT随肝纤维化程度加重逐渐升高,差异有统计学意义(P<0.05).Spearman相关性分析示:ALT、AST、GGT、TB、GLO、PT、RDW、MPV、年龄与肝纤维化呈正相关;ALB、白细胞计数、HB、PLT与肝纤维化呈负相关.在Logistic回归分析中,PLT是明显肝纤维化的独立危险因素.结论:ALT不是反映肝纤维化程度的较好指标,血小板是明显肝纤维化的独立危险因素.因此,对于年纪大,血小板降低的CHB患者,即使ALT正常或轻度升高,也应行肝组织学评估.

AIM： To investigate the relationship between the severity of fibrosis and clinical parameters in patients with chronic hepatitis B （CHB）, and to analyze risk factors for significant liver fibrosis in CHB patients. METHODS： A total of 76 biopsy-proven CHB cases treated from January 2012 to July 2015 at the Second Hospital Affiliated to Kunming Medical University were included in the study. Gender, age, blood count variables including white blood cells, hemoglobin （HB）, platelet count （PLT）, red blood cell distribution width （RDW）, mean platelet volume （MPV）, as well as albumin （ALB）, globin （GLO）, alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, alkaline phosphatase （ALP）, gamma-glutamyl transpeptidase （GGT）, total bilirubin （TB）, prothrombin time （PT） and serum HBV DNA were recorded. Relationship between these parameters and liver fibrosis stage and risk factors for significant liver fibrosis were analyzed. RESULTS： With the increase in the severity of liver fibrosis, white blood cells, HB, PLT, and ALB gradually decreased, and RDW, GLB, AST, PT, GGT increased; all of these parameters had significant differences between the $1-$4 groups （P 〈 0.05）. Spearman correlation analysis showed that there was apositive correlation between ALT, AST, GGT, TB, GLO, PT, RDW, MPV, age and liver stage of fibrosis, and a negative correlation between liver stage of fibrosis and ALB, white blood cells, HB, and PLT. In logistic regression analysis, PLT was identified as an independent risk factor for significant liver fibrosis in CHB. CONCLUSION： ALT is not predictive of liver fibrosis stage. PLT is an independent risk factor for significant liver fibrosis in CHB. Liver histopathology can be recommended for CHB patients with older age, lower PLT, even though ALT is normal or only mildly elevated.