比索洛尔对慢性阻塞性肺病患者肺功能及相关炎性介质表达的影响

Effect of Bisoprolol on the Lung Fucntion of Patients with Chronic Obstructive Pulmonary Disease and the Expression of Inflammatory Medium

目的探究并分析比索洛尔对慢性阻塞性肺疾病(COPD)患者肺功能及相关炎性介质表达的影响。方法选取2013年1月至2015年6月滁州市第一人民医院收治的COPO患者100例,按照随机数字表法分为对照组和观察组,各50例。对照组口服0.5 mg羧甲司坦片,每日3次;观察组患者在对照组的基础上口服比索洛尔初始剂量为1.25 mg,每日1次,如无不良反应,7 d后加量至2.5 mg。观察并记录两组患者肺功能以及相关炎性介质的变化。结果两组患者治疗后动脉血氧饱和度(Sa O2)高于治疗前、动脉血二氧化碳分压(Pa CO2)低于治疗前(P<0.05),观察组患者治疗后Sa O2高于对照组,Pa CO2明显低于对照组[(0.982±0.013)比(0.892±0.032)、(42.4±2.9)mm Hg(1 mm Hg=0.133 k Pa)比(51.2±3.7)mm Hg,P<0.05],差异有统计学意义(P<0.01)。两组患者治疗后3个月、治疗后6个月第一秒用力呼气量呈上升趋势(P<0.05),且观察组上升速度更快(P<0.05)。两组患者治疗后3个月、治疗后6个月C反应蛋白呈下降趋势(P<0.05),且观察组下降速度更快(P<0.05)。观察组治疗后3个月、治疗后6个月淀粉样蛋白A呈下降趋势,对照组呈上升趋势(P<0.05),且观察组治疗后6个月低于对照组(P<0.05)。结论比索洛尔能有效改善COPD患者的呼吸功能,提高患者氧合能力,并降低炎症反应,改善患者病情。

Objective To explore and analyze the effects of bisoprolol on the lung function of patients with chronic obstructive pulmonary disease （COPD） and expression of inflammatory medium. Methods Total of 100 patients with COPD were chosen from Chuzhou First People＇s Hospital from Jan. 2013 to Jun. 2015, and they were divided into control group and observation group with 50 cases in each group, according to random number table method. The control group was treated with 0. 5 mg carbocisteine tablets,3 times a day; the observation group was added with bisoprolol 1.25 mg as the starting dose on the basis of the control group＇s therapy,once per day,and if no adverse reactions,after 7 d increased to 2.5 mg. Pulmonary function and inflammatory medium changes otThe two groups were observed and recorded. Results After treatment, oxygen saturation（ SaO2 ） of both groups was higher than before treatment, carbon dioxide partial pressure （PaCO2 ） was lower than before treatment （P 〈 0. 05 ）. After treatment, SaO2 of the observation group was higher than the control group, PaCO2 was significantly lower than the control group [ （0. 982 ± 0. 013 ）vs （0.892±0.032）,（42.4 ±2.9） mmHg vs （51.2±3.7） mmHg,P〈0.01].3 months,6 months after treatment, the forced expiratory volume in one second （FEV1 ） showed an upward trend （P 〈 0. 05 ）, and the observation group increased faster（ P 〈 0. 05 ） ;the C-reactive protein（CRP） both showed a downtrend （P 〈 0.05 ）, and the observation group decreased faster（ P 〈 0.05 ）. SAA of the observation group decreased, while the control group increased（P 〈 0. 05 ）, and at 6 months after treatment, SAA of the observation group was lower than the control group （ P 〈 0. 05 ）. Conclusion Bisoprolol can effectively improve the respiratory function of COPD patients,improve the oxygenation capacity and reduce the inflammatory reaction, therefore improve the patient＇s condition.