摘要
放射性核素标记的乏氧显像是评估肿瘤乏氧程度的重要方法,乏氧显像剂可以选择性地滞留于乏氧组织内,直观反映乏氧的部位和乏氧的程度,对肿瘤诊断、分期、疗效监测及预后评估等有指导意义,同时也为临床选择及调整肿瘤治疗方案提供了客观依据.笔者主要对肿瘤乏氧PET显像近年来在临床研究中的进展及与肿瘤乏氧相关的治疗进展进行综述.
Assessing tumor hypoxia with metabolic imaging is an attractive alternative.Hypoxia tracers bind selectively to hypoxic cells, using PET with specific radiopharmaceuticals could visualize hypoxia noninvasively.Hypoxia PET imaging is a valuable tool in assessing oxygenation levels in tumors for the purpose of tumor diagnosis and also as a prognostic indicator.Meanwhile, hypoxia imaging can quantify hypoxic tumor subvolumes for dose painting and personalized treatment planning and delivery.This review summarizes the published literature on clinical studies and the experimental treatment of tumor hypoxia.
出处
《国际放射医学核医学杂志》
2016年第1期35-43,共9页
International Journal of Radiation Medicine and Nuclear Medicine
基金
国家自然科学基金（NSFC8141708）
