应用间充质干细胞治疗急性辐射损伤的研究现状与进展

Recent advances in the application of mesenchymal stem cells for treatment of acute radiation injury

间充质干细胞是一类来源广泛的低免疫原性多能干细胞,具有多向分化、造血支持、免疫调控等特点,且易于分离、扩增和外源基因转染,在临床治疗中有广泛的应用价值,其用于急性放射损伤治疗的报道也较多.笔者主要介绍了间充质干细胞治疗急性放射损伤的研究现状和相关进展.

Mesenchymal stem cells （MSCs） are a source of various multipotent stromal cells with low inherent immunogenicity.These cells can undergo multi-directional differentiation, support hematopoiesis, and regulate immune responses.MSCs can be easily collected and amplified.These cells can also be transfected using an exogenous gene.MSCs have been extensively applied in clinical treatments, such as in the therapy for acute radiation injury.This study was primarily performed to investigate the effect and mechanism of MSCs in acute radiation injury.